A DNA aptamer to c-Met inhibits cancer cell migration.
نویسندگان
چکیده
The HGF/c-Met pathway is known to play a key role in cancer metastasis. CLN0003_SL1, a 50-mer DNA aptamer that binds to the c-Met protein, was found to inhibit HGF-induced c-Met activation. This aptamer could suppress cancer cell motility in vitro.
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عنوان ژورنال:
- Chemical communications
دوره 50 86 شماره
صفحات -
تاریخ انتشار 2014